ABSTRACT
Objective: To study change of serum high sensitive cardiac troponin T (hscTnT) concentration in coronary circulation of patients with non ST-elevation acute coronary syndrome (NSTE-ACS). Methods: The subjects were all selected from our hospital, including 46 NSTE-ACS patients （NSTE-ACS group）, 42 patients with stable angina pectoris (SAP group) and 30 cases with negative coronary angiography results（healthy control group）The hscTnT concentrations in coronary venous sinus, coronary artery (CA) and peripheral serum were measured in three groups respectively. The results were compared and analyzed. Results: Compared with healthy control group, the hscTnT concentrations in coronary venous sinus, CA and peripheral venous serum all significantly increased in NSTE-ACS group and SAP group, P<0.01 all. Compared with hscTnT levels in CA and peripheral venous serum, there was significant increase in coronary venous sinus [(0.9657±0.5863) μg/L vs. (0.9562±0.7853) μg/L vs. (1.3018±1.1024) μg/L, P<0.05] in NSTE-ACS group. Conclusion: The serum hscTnT concentrations in peripheral vein, coronary artery and coronary venous sinus all significantly increase in NSTE-ACS patients, especially in coronary venous sinus.
ABSTRACT
OBJECTIVE:To study the effect of losartan on heart rate variability of essential hypertensive patientsMETHO_DS:The heart rate power spectral density and time-domain in 24-hour dynamic EKG were analyzed in 50 healthy subjects and in 90 patients with hypertension before and after giving losartanRESULTS:The low frequency and total frequency and ratio between low frequency and high frequency of hypertensive patients were significantly higher than those of controls,the high frequency and standard deviation of normal-to-normal intervals(SDNN) and standard deviation of the average of RR intervals(SDANN) for each five-minute period of the 24-hour eletrocardiographic recordings were significantly lower than those of controlsThe SDNN and high frequency of grade Ⅲ hypertension were significantly lower than those of grade Ⅱ hypertensionThe low frequency and ratio between low frequency and high frequency of grade Ⅲ hypertension were significantly higher than those of grade Ⅱ hypertension,and so were the grade Ⅱ than those of the grade Ⅰ It showed that vegetative nerve functi_onal damage was positively related with hypertensive gradeThe severer the illness,the greater the changeAfter losartan treatment,in addition to lowing the blood pressure,the SDNN,SDANN and high frequency of hypertensive patients were significantly increasedThe low frequency,total frequency and ratio between low frequency and high frequency of hypertensive patients were significantly decreasedCONCLUSION:When losartan lowers blood pressure,it can significantly improve the heart rate variability of essential hypertensive patients